细胞遗传学和癌基因异常急性淋巴细胞白血病(ALL)常有细胞遗传学的异常.B系ALL最常见的易位为t(1;19)、t(4;11)、t(11;l4)和t(9;22).L3表型ALL(成热B细胞白血病)的典型异常与Burkitt淋巴瘤类似,包括t(8;14)、t(2;8)或伴断裂点在14号染色体的免疫球蛋白重链位点或者在2或22号染色体的轻链位点邻近的t(8;22).T-ALL易位,包括14倒位、t(4;14)和t(10;14)常发生在14号染色体上T细胞受体的α Cytogenetics and oncogene abnormalities Acute lymphoblastic leukemia (ALL) is often associated with cytogenetic abnormalities. The most common translocations in B lineage ALL are t (1; 19), t (4; 11), t (11; 14 ) And t (9; 22). The typical anomalies of L3 phenotype ALL are similar to Burkitt’s lymphoma and include t (8; 14), t (2; 8) The chromosomal immunoglobulin heavy chain site or t (8; 22) .T-ALL translocations, including 14 inversions, t (4; 14) and t 10; 14) Occurs frequently on T cell receptor α on chromosome 14