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目的:探讨中药疏肝颗粒对实验性肝损伤的小鼠 AST。、TBil、MDA。SOD 含量的影响及肝组织病理形态学的影响。方法:0.2%四氯化碳腹腔注射造成小鼠肝损伤模型,采用试剂盒测定小鼠血清中 AST、Tbil 含量及肝匀浆中 MDA、SOD 的含量;肝组织常规切片、HE 染色,光镜下进行组织病理学检查。结果:中药疏肝颗粒使 CCl_4致肝损伤的小鼠的 AST、Tbil 含量降低,MDA 含量降低,SOD 含量升高;对 CCl_4所致肝损伤的小鼠肝细胞坏死具有明显改善作用。结论:中药疏肝颗粒对 CCl_4致肝损伤的小鼠具有一定的保护作用。
OBJECTIVE: To investigate the effect of Chinese herbal medicine Shugan granule on experimental liver injury in mice. , TBil, MDA. Effects of SOD content and histopathological effects on liver tissue. METHODS: Mouse liver injury model was induced by intraperitoneal injection of 0.2% carbon tetrachloride. Kits were used to determine the serum AST and Tbil levels and the contents of MDA and SOD in the liver homogenate. Liver tissues were routinely sectioned and HE stained. Under histopathological examination. RESULTS: The Chinese medicine Shugan granules decreased the AST and Tbil content in mice with liver injury induced by CCl_4, decreased the content of MDA, and increased the content of SOD. The liver necrosis of mice with CCl_4 induced liver injury was significantly improved. Conclusion: The traditional Chinese medicine Shugan granule has protective effect on mice with hepatic injury induced by CCl_4.