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实验猪在常规麻醉下开胸,分离左前降支。阻断左前降支远端造成局部心肌缺血45分钟,然后恢复灌注。3天后再次麻醉开胸并复查。在恢复左前降支血流前1分钟和恢复灌注头45分钟内,向冠状动脉内注入下列溶液。50头猪等分成5组。D 组注入地尔硫(艹卓)(前16分钟0.25mg/min,后30分钟0.125mg/min)。N 组注入硝苯啶(前16分钟0.5
Experimental pigs underwent thoracotomy under general anesthesia, isolated left anterior descending branch. Blocking the distal left anterior descending artery caused local myocardial ischemia for 45 minutes and then resumed perfusion. Three days later anesthesia thoracotomy and review. The following solutions were injected into the coronary arteries 1 minute before recovery of the left anterior descending branch blood flow and 45 minutes after the reinfusion head. 50 pigs divided into 5 groups. D group was injected with diltiazem (0.25 mg / min for the first 16 minutes and 0.125 mg / min for the last 30 minutes). N group injected with nifedipine (the first 16 minutes 0.5