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目的建立奥硝唑凝胶剂中奥硝唑的含量测定方法。方法采用一阶导数光谱法,样品不经分离直接测定奥硝唑凝胶剂中奥硝唑的含量,以波长296nm与262nm间的振幅值(D)作为定量依据。结果线性范围为8.0~80.0μg·mL~(-1),r=-0.9999,平均回收率为100.71%,RSD为0.89%。结论本法简便、快速、准确,可作为该制剂的质量控制方法。
Objective To establish a method for the determination of ornidazole in ornidazole gel. Methods The first order derivative spectrometry was used to determine the content of ornidazole in the ornidazole gel without separation. The amplitude (D) between 296nm and 262nm was used as the quantitative basis. The linear range was 8.0 ~ 80.0 μg · mL -1, r = -0.9999. The average recovery was 100.71% and the RSD was 0.89%. Conclusion This method is simple, rapid and accurate and can be used as the quality control method of this preparation.