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烟草对胎盘和胎儿的致癌和致畸成分相当多,如镉等可以损伤胎盘血管系统和引起某些酶失活,但对胚胎细胞代谢的影响却知之尚少。为了解主动吸烟对妊娠早期胎儿血浆游离氨基酸和酶的影响进行研究。 胎儿血、胎肝和母亲静脉血样本均采自18例健康孕妇,妊娠期为12～17周,在全麻下行宫颈扩张术和刮宫术终止妊娠。研究组包括9例长期严重吸烟(15～25支/d)的孕好和9例不吸烟孕妇,采集样本时把尿中所检测到烟碱水平与其报告吸烟程度不
Tobacco on the placenta and fetus carcinogenic and teratogenic ingredients quite a lot, such as cadmium can damage the placental vascular system and cause some enzyme inactivation, but the impact on embryo cell metabolism is still little known. In order to understand the impact of active smoking on fetal plasma free amino acids and enzymes during early pregnancy. Fetal blood, fetal liver and mothers venous blood samples were collected from 18 healthy pregnant women, gestational age of 12 to 17 weeks, under general anesthesia cervical dilatation and curettage termination of pregnancy. The study group included 9 cases of long-term serious smoking (15 to 25 cigarettes / d) and 9 non-smoking pregnant women. When collecting samples, the level of nicotine detected in the urine and the level of smoking not reported