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目的:探讨硫酸镁联合甘露醇治疗急性胰腺炎的临床疗效。方法:选取2015年1月~2016年10月收治的86例急性胰腺炎患者作为研究对象,按随机数字表法将86例分为观察组和对照组各43例,对照组给予常规治疗,观察组则在对照组治疗基础上给予硫酸镁联合甘露醇治疗,观察两组患者的临床疗效,腹痛缓解时间,血、尿淀粉酶,血白细胞,体温及排便恢复正常时间,住院时间,手术治疗及病死率等。结果:观察组总有效率为93.02%,明显高于对照组的81.39%,差异有统计学意义(P<0.05),观察组腹痛缓解时间,血、尿淀粉酶,血白细胞计数,体温及排便恢复时间,住院时间等指标均显著优于对照组,差异亦有统计学意义(P<0.05)。观察组转外科手术治疗4例(9.30%),少于对照组的8例(18.60%),死亡1例(2.32%),少于对照组的5例(11.62%)。结论:硫酸镁联合甘露醇治疗急性胰腺炎可有效改善临床症状,提高疗效,是治疗急性胰腺炎安全、有效的方法。
Objective: To investigate the clinical efficacy of magnesium sulfate combined with mannitol in the treatment of acute pancreatitis. Methods: A total of 86 patients with acute pancreatitis admitted from January 2015 to October 2016 were enrolled in this study. According to the random number table method, 86 cases were divided into observation group and control group, 43 cases in each group. The control group was given routine treatment and observation The patients in the control group were treated with magnesium sulfate combined with mannitol. The clinical efficacy, abdominal pain relief time, blood and urine amylase, white blood cells, body temperature and defecation recovery time, hospitalization time, operation and Fatality rate and so on. Results: The total effective rate in the observation group was 93.02%, which was significantly higher than that in the control group (81.39%), the difference was statistically significant (P <0.05). The pain relief time, blood amylase, white blood cell count, body temperature and defecation Recovery time, hospital stay and other indicators were significantly better than the control group, the difference was statistically significant (P <0.05). There were 4 cases (9.30%) in surgery group, 8 cases (18.60%) less than the control group, 1 case (2.32%) died and 5 cases (11.62%) less than the control group. Conclusion: Magnesium sulfate combined with mannitol in the treatment of acute pancreatitis can effectively improve the clinical symptoms and improve the curative effect. It is a safe and effective method for the treatment of acute pancreatitis.