以健脾益气中药为主的“胃粘膜保护方”(GMP)对大鼠急性乙醇性胃粘膜损伤具有细胞保护作用,使之不出观肉眼损伤,显微镜下损伤及胃粘膜跨膜电位差(PD)的下降亦明显减轻。提示中医脾胃与胃粘膜屏障有一定关系。GMP能提高胃粘膜防御能力,对某些有胃粘膜损伤的疾病,可能具有预防及治疗作用。 The “Gastroprotective Formula” (GMP), which is mainly based on spleen and Qi herbs, has cytoprotective effect on acute alcoholic gastric mucosal damage in rats, which makes it possible to avoid macroscopic damage, microscopic damage, and the transmembrane potential difference of gastric mucosa. The decrease in (PD) was also significantly reduced. It suggests that there is a certain relationship between the spleen and stomach of the TCM and the gastric mucosal barrier. GMP can improve gastric mucosal defense ability, and may have preventive and therapeutic effects on certain diseases with gastric mucosal injury.