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【目的】探讨香莲外洗液诱导白念珠菌阴道分离耐药株恢复对氟康唑的敏感性。【方法】香莲外洗液作用于白念珠菌阴道分离耐药株,采用肉汤微量稀释法测定氟康唑对原代及每代菌株的最低抑菌浓度(MIC)值,从而判断白念珠菌阴道分离耐药株恢复对氟康唑敏感所需的代数。【结果】经香莲外洗液作用后,临床耐药菌株A1～A10分别于第8、5、6、7、10、5、7、8、6、7代恢复对氟康唑敏感,而无香莲作用的耐药试验菌株白念珠菌A1～A10则分别在第19、14、15、12、17、12、17、19、14、17代恢复对氟康唑敏感。【结论】香莲外洗液能较快诱导临床耐药白念珠菌恢复对氟康唑的敏感性。
【Objective】 To investigate the sensitivity of Xianglian external washings to the recovery of fluconazole induced by Candida albicans vaginal drug-resistant strains. 【Method】 The lotus lotion was applied to the vaginal drug-resistant strains of Candida albicans. The minimal inhibitory concentration (MIC) of fluconazole against primary and each strain was determined by broth microdilution method, Viable vaginal isolates resistant to aldosterone required to restore susceptibility to fluconazole. 【Result】 The results showed that the resistant strains A1 ~ A10 recovered to fluconazole on the 8th, 5th, 6th, 10th, 10th, 5th, 7th, Candida albicans A1 to A10 showed no sensitivity to fluconazole on the 19th, 14th, 15th, 12th, 17th, 12th, 17th, 19th, 19th, 14th and 17th generation, respectively. 【Conclusion】 Xianglian external lotion can quickly induce clinical drug-resistant Candida albicans to restore its sensitivity to fluconazole.