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[目的]研究骨肉瘤组织中VEGF和PTEN的表达及相关性,为治疗骨肉瘤与评估预后提供理论依据。[方法]应用免疫组织化学方法对40例骨肉瘤和20例骨软骨瘤标本进行检测,并利用SPSS12.0软件进行数据分析其表达意义和相关性。[结果]骨肉瘤中VEGF表达率为57.5%(23/40),在骨软骨瘤中不表达。VEGF在骨肉瘤和骨软骨瘤中阳性表达率有显著性差异(χ2=18.65,P<0.05)。骨肉瘤中PTEN表达率为55.0%(22/40),在骨软骨瘤中表达率为90.0%(18/20)。PTEN在骨肉瘤和骨软骨瘤中阳性表达率有显著性差异(χ2=7.35,P<0.05)。VEGF和PTEN在骨肉瘤中的阳性表达呈负相关(r=-0.3710,P=0.0189)。[结论]联合检测骨肉瘤组织PTEN、VEGF,作为判定骨肉瘤侵袭转移能力的一项客观指标,可能对骨肉瘤的预后判断具有重要意义,PTEN表达阳性而VEGF表达阴性者,可能预后较好。
[Objective] To study the expression and correlation of VEGF and PTEN in osteosarcoma and to provide a theoretical basis for the treatment of osteosarcoma and prognosis. [Methods] 40 cases of osteosarcoma and 20 cases of osteochondroma specimens were detected by immunohistochemical method. The significance of the expression and the correlation were analyzed by SPSS 12.0 software. [Results] The expression rate of VEGF in osteosarcoma was 57.5% (23/40), which was not expressed in osteochondroma. The positive rate of VEGF in osteosarcoma and osteochondroma was significantly different (χ2 = 18.65, P <0.05). The expression rate of PTEN in osteosarcoma was 55.0% (22/40), and in osteochondroma, 90.0% (18/20). The positive expression rates of PTEN in osteosarcoma and osteochondroma were significantly different (χ2 = 7.35, P <0.05). The positive expression of VEGF and PTEN in osteosarcoma was negatively correlated (r = -0.3710, P = 0.0189). [Conclusion] The combined detection of PTEN and VEGF in osteosarcoma tissue may be an objective index to evaluate the invasion and metastasis of osteosarcoma. It may be of great significance for the prognosis of osteosarcoma. The positive prognosis of PTEN and PTEN may be related to the prognosis of osteosarcoma.