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目的观察甲氰咪胍、潘生丁、硝苯地平对过敏性紫癜的疗效并探讨其机理。方法确诊病例随机分治疗组65例,对照组51例,对照组采用常规治疗,治疗组在常规治疗的基础上,加用甲氰咪胍10~15mg/kg.d-1,加入5%葡萄糖液静脉滴注,每日1次,潘生丁5~7mg/kg.d-1,硝苯地平2~3mg/kg.d-1,分3次口服,并分别观察患儿皮疹、关节肿痛、消化道症状、蛋白尿及血尿消失的时间。结果治疗组和对照组皮肤症状、关节症状、消化道症状在治疗后消失的时间分别为:5.78±1.85天,3.98±1.35天、4.66±1.27天,而对照组分别为9.54±2.61天、4.58±1.65天、6.78±2.03天,两者间差异有显著性(P<0.05或0.01);在蛋白尿、血尿消失方面,治疗组为6.46±2.51天、7.96±2.36天,而对照组为9.88±2.87天、17.55±2.73天,两者间差异有高度显著性(P<0.01)。结论甲氰咪胍、潘生丁、硝苯地平联合治疗过敏性紫癜作用迅速,疗效显著,治愈率高,不易复发,无明显不良反应,是治疗过敏性紫癜安全有效的药物。
Objective To observe the effect of cimetidine, dipyridamole and nifedipine on allergic purpura and to explore its mechanism. Methods Totally 65 cases were randomly divided into treatment group (n = 51) and control group (n = 51). The control group was treated with conventional therapy. The treatment group was given cetamidine 10-15mg / kg.d- Liquid intravenous drip once a day, dipyridamole 5-7mg / kg.d-1, nifedipine 2 ~ 3mg / kg.d-1, 3 times orally, and were observed in children with rash, joint swelling and pain, Gastrointestinal symptoms, proteinuria and hematuria disappear time. Results The disappearance time of skin symptoms, joint symptoms and gastrointestinal symptoms in treatment group and control group after treatment were 5.78 ± 1.85 days, 3.98 ± 1.35 days and 4.66 ± 1.27 days respectively, while the control group were 9.54 ± 2.61 days and 4.58 ± 1.65 days and 6.78 ± 2.03 days respectively, there was significant difference between the two groups (P <0.05 or 0.01); in proteinuria and hematuria disappearance, the treatment group was 6.46 ± 2.51 days and 7.96 ± 2.36 days, while the control group was 9.88 ± 2.87 days, 17.55 ± 2.73 days, the difference was highly significant (P <0.01). Conclusion Cimetidine, dipyridamole and nifedipine are effective in the treatment of allergic purpura. The curative effect is obvious, the cure rate is high, the relapse is easy, and no obvious adverse reactions are seen. It is a safe and effective drug for the treatment of allergic purpura.