现在一般认为胆盐和阻塞性黄疸时的瘙痒症有关,其最有力证据为Schoenfield等(1967)发现有瘙痒症的黄疸病人皮肤中含有的胆盐浓度较无瘙痒症的同类患者为高,且在瘙痒消失的同一天降至正常水平。但在全血胆盐浓度与瘙痒剧度之间未见明显相关,用胆盐涂敷皮肤或离子透入均未能引发瘙痒,口服粗制胆盐虽曾在少数胆汁性肝硬化病人中引起瘙痒加剧,但静脉注射或口服纯胆酸盐并未引起瘙痒,故上述证据尚乏充分的说服力。如果各种胆盐引发瘙痒的能力有所不同,上述矛盾或可得以解释,近来有两组作者提出了支持这 It is now generally believed that bile salts are associated with pruritus at the time of obstructive jaundice and the strongest evidence for this is that Schoenfield et al. (1967) found that the skin of patients with pruritus jaundice contains bile salts of higher concentrations than the primed patients without pruritus and On the same day itch disappeared to normal levels. However, there was no significant correlation between whole blood bile salt concentration and pruritus degree of severity. Biliary salt-coated skin or iontophoresis failed to cause pruritus. Oral administration of crude bile salt was caused in a few patients with biliary cirrhosis Pruritus exacerbated, but intravenous or oral administration of pure bile salts did not cause itching, so the above evidence is still not convincing enough. If the ability of various bile salts to cause pruritus is different, these contradictions may be explained, and recently two groups of authors have proposed to support this