汗管角化具有广泛多样比的临床和形态学表现。但最少见的是播散性掌跖汗管角化(PPPD),Guss等首先描述了本病,而后Brasch等,shaw和white先后报导,我们在此描述第四个家族患病情况。 本例患者男性,58岁,在青春期后不久由于掌跖角化突出物发展引起阵发性疼痛而首次就诊。而后角化物逐年增多,发展到四肢,躯干和颈部。患者其他健康。 体检发现在四肢,躯干、颈部有色素沉 The keratoderma has a wide range of clinical and morphological manifestations. However, the least common is diffuse disseminated palmar keratoderma (PPPD). Guss et al. first described the disease. Later Brasch et al., shaw and white reported that we describe the fourth family’s prevalence. The male patient in this case, 58 years old, presented for the first time after puberty due to paroxysmal pain caused by the development of palmar hyperkeratotic neurites. The postcornuates have increased year by year and have developed into limbs, trunk and neck. The patient is otherwise healthy. Physical examination found in the limbs, pigmentation in the trunk and neck