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目的:探讨胃肠进外间质瘤(extra-gastrointestinal stromal tumor,EGIST).尤其膀胱间质瘤的临床表现、诊断与治疗。方法:报告我院于2010年6月1日～7月12日收治的1例膀胱间质瘤患者的临床资料并对相关文献进行复习。结果:本例患者行膀胱全切术。病理结果:光镜下见黏膜上皮增生,Brunn巢形成;免疫组化染色:CD117阳性.诊断为膀胱间质瘤。术后定期随访未见肿瘤复发及转移。结论:膀胱间质临床上罕见.无特征性临床术表观,治疗以手术切除为主。转移和不能手术切除的患者采用分子靶向治疗。
Objective: To investigate the clinical features, diagnosis and treatment of extra-gastrointestinal stromal tumor (EGIST). Methods: The clinical data of one case of bladder stromal tumor admitted to our hospital from June 1 to July 12, 2010 were reviewed and the related literatures were reviewed. Results: The patients underwent total cystectomy. Pathological results: Under the light microscope, mucosal epithelial hyperplasia and Brunn nest formation were observed.Immunohistochemical staining: CD117positive.The diagnosis of bladder stromal tumor. Regular follow-up no tumor recurrence and metastasis. Conclusions: Bladder interstitial is rare in clinical practice, with no apparent clinical manifestations. The surgical treatment is mainly surgical resection. Patients with metastases and unresectable patients were treated with molecular targeted therapy.