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溶血磷脂酸(lysophosphatidic acid,LPA)在高浓度时( >50μmol/L)显示出对培养大脑皮层神经元致凋亡特性。本研究旨在初步分析溶血磷脂酸致凋亡过程中对相关基因表达的依赖性,在研究中结合琼脂糖电泳,HO33342染色和TUNEL技术观察c-fos,bax和p53三种反义寡聚核苷酸对溶血磷脂酸致培养大脑皮层神经元致凋亡的影响。结果显示结合c-fos, bax和p53三种反义寡聚核苷酸均表现出对溶血磷脂酸致凋亡的神经保护作用。溶血磷脂酸的致凋亡过程为c-fos,bax和p53基因依赖性,不同于b淀粉样蛋白片段31 -35的致凋亡特性。
Lysophosphatidic acid (LPA) shows apoptosis-inducing effect on cultured cortical neurons at high concentrations (> 50 μmol / L). The aim of this study was to initially analyze the dependence of lysostaphin on the expression of related genes during the apoptotic process. The antisense oligonucleotides of c-fos, bax and p53 were observed by agarose gel electrophoresis, HO33342 staining and TUNEL technique Effects of Glyoxalate on Apoptosis of Cerebral Cortex Neurons Induced by Lysophosphatidic Acid. The results showed that the combination of c-fos, bax and p53 three antisense oligonucleotides showed a neuroprotective effect of apoptosis caused by lysophosphatidic acid. The apoptotic process of lysophosphatidic acid is dependent on the c-fos, bax and p53 genes, which is different from the apoptotic characteristics of b-amyloid fragment 31-35.