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胆固醇能使血管壁内皮细胞的肌球蛋白收缩加强,导致细胞间隙增大,β脂蛋白和前β脂蛋白易于通过细胞间隙进入并沉积于内皮下形成脂斑;胆固醇还能使血小板聚积,促进动脉硬化斑块形成。因此,以胆固醇喂养家兔一定时间后,可以产生实验性动脉粥样硬化cAMP是血小板聚积的温和抑制剂,又是内皮细胞的松弛剂。cAMP含量降低,可以使血小板聚集性增高,内皮细胞收缩加强,产生动脉粥样硬化;静脉注入大量外源性cAMP,
Cholesterol can enhance the contraction of myosin in the vascular wall endothelial cells, resulting in increased cell gap, beta lipoprotein and pre-beta lipoprotein easy to enter through the cell gap and deposited in the endothelium to form the plaque; cholesterol can also platelet accumulation, and promote Atherosclerosis plaque formation. Therefore, cholesterol-fed rabbits for a certain period of time can produce experimental atherosclerosis cAMP is a mild inhibitor of platelet aggregation, but also a relaxation agent of endothelial cells. cAMP decreased, can increase platelet aggregation, endothelial cell contraction strengthened, resulting in atherosclerosis; intravenous injection of a large number of exogenous cAMP,