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作者于1981～1987年为12例首次或第二次完全缓解(CR)的急性髓性白血病(AML)施行了自身外周血干细胞移植(ABSCT)。方法和结果 5例年龄19～50(平均36)岁,是在第1次 CR 后。采用柔红霉素(DNR)60mg/M~2/d×3静注,阿糖胞苷(Ard-C)100mg/M~2/d×10持续静脉滴注,一疗程化疗达 CR;然后用大剂量 Ara-C3.0/M~2×8及 DNR45mg/M~2×3作巩固治疗。每个患者在骨髓增生期进行5～6次白细胞单采以收集外周血干细胞.白细胞单采后4周,给予马利兰4mg/kg/d×4
The authors performed autologous peripheral blood stem cell transplantation (ABSCT) in 12 patients with acute myeloid leukemia (AML) in their first or second complete remission (CR) from 1981 to 1987. Methods and Results Five patients aged 19 to 50 (mean, 36) years old were after the first CR. The patients were treated with daunorubicin (DNR) 60mg / M ~ 2 / d × 3 intravenously and Ard-C 100mg / M ~ 2 / d × 10. With large doses of Ara-C3.0 / M ~ 2 × 8 and DNR45mg / M ~ 2 × 3 for consolidation therapy. Peripheral blood stem cells were harvested 5 to 6 times during the myeloproliferative phase in each patient.4 weeks after leukocyte apheresis, 4 mg / kg / d × 4