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目的:观察老年女性骨质疏松症(OP)患者静滴唑来膦酸后急性期反应(APR)的发生情况。方法:47例老年女性OP患者静滴唑来膦酸注射液5 mg后,记录她们在72 h内发热、肌痛、流感样症状、头痛头晕、恶心呕吐等APR的发生情况。结果:35例(74.47%)患者出现1个或1个以上的APR,其中发热19例(40.43%),肌痛18例(38.30%),流感样症状14例(29.79%),头痛头晕13例(27.66%),恶心呕吐12例(25.53%)。发热患者伴随其他APR的平均个数(3.35±1.41)个明显高于不发热的患者的平均个数(1.40±0.63)个,差异有统计学意义(P<0.01)。且在发热患者中,最高体温与其他APR间具有相关性(r=0.577,P<0.05)。结论:老年女性OP患者静脉输注唑来膦酸后,易出现发热等APR,应重视静脉输注后的观察和处理。
Objective: To observe the incidence of acute phase response (APR) after the intravenous infusion of zoledronic acid in elderly female patients with osteoporosis (OP). Methods: Forty-seven elderly female patients with OP were treated with 5 mg intravenous injection of zoledronic acid and recorded the incidence of APR such as fever, myalgia, flu-like symptoms, headache and dizziness, nausea and vomiting within 72 hours. Results: One or more APR occurred in 35 patients (74.47%), including 19 cases of fever (40.43%), 18 cases of myalgia (38.30%), 14 cases of flu-like symptoms (29.79% Cases (27.66%), nausea and vomiting in 12 cases (25.53%). The average number of fever patients with other APR (3.35 ± 1.41) was significantly higher than the average number of patients without fever (1.40 ± 0.63), the difference was statistically significant (P <0.01). And in fever patients, the highest body temperature was correlated with other APR (r = 0.577, P <0.05). CONCLUSION: APR in females with OP after intravenous infusion of verapamil is prone to fever and other APR. The observation and treatment after intravenous infusion should be emphasized.