消炎痛 (indomethacinIN)多年来被用作缓解风湿性疾病症状和治疗多种关节炎的药物。研究发现IN有一定的抗肿瘤作用 ,IN主要抑制环氧化酶 ,从而抑制对肿瘤生长和转移具有明显促进作用的PGE2 或其它PGS的产生。IN还通过抑制细胞增殖、诱导细胞凋亡 ,降低肿瘤组织血管的渗透性等作用发挥其抗肿瘤的作用。 IndomethacinIN has been used for many years as a medicament for alleviating the symptoms of rheumatic diseases and for treating a variety of arthritis. The study found that IN has a certain anti-tumor effect, IN mainly inhibit cyclooxygenase, thereby inhibiting the growth of tumor and metastasis significantly promote the production of PGE2 or other PGS. IN also exerts its antitumor effect by inhibiting cell proliferation, inducing apoptosis and reducing the permeability of tumor tissue blood vessels.