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用NITT法检测补骨脂素、α_1干扰素及两者联合应用对人粘浓表皮样癌细胞系MEC-1的生长抑制作用,它们的半抑制浓度(IC_(50))分别为5248ng/ml和44668μ/ml,两者联合应用耒显示山拮抗、相加或协同作用。补骨脂素、α_1干扰素及两者联合应用对MEC-1细胞裸鼠移植瘤的抑瘤率分别为79.1％、38.5％和82.6％;受试鼠的体重变化率分别为减轻5％、减轻2％和增加1.3％,生命延长率分别为122.4％、36.4％和148.6％。结果提示联合用药明显改善了试验动物的全身状况,延长了生存期。
The NITT assay was used to detect the growth inhibitory effect of psoralen, interferon alfa-1, and their combination on the human viscid epithelial carcinoma cell line MEC-1. Their half inhibitory concentrations (IC_(50)) were 5248 ng/ml, respectively. Combined with 44668μ/ml, 耒 showed antagonistic, additive or synergistic effects. The tumor inhibition rates of psoralen, α_1 interferon, and their combination on MEC-1 cells in nude mice were 79.1%, 38.5%, and 82.6%, respectively; the body weight change rate of mice in the experiment was 5%. With a 2% reduction and a 1.3% increase, the life extension rates were 122.4%, 36.4%, and 148.6%, respectively. The results suggest that combination therapy significantly improves the overall condition of the experimental animal and prolongs survival.