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目的:研究金地鼠颊囊白斑癌变过程中端粒酶活性的动态变化规律,为探讨药物干预口腔白斑癌变可能作用机制提供基线资料。方法:以Salley法建立金地鼠颊囊癌变模型,55只金地鼠分两组:对照组(A组)5只;模型组(B组)50只。双盲法判别病理分级;TRAP-ELISA法检测标本端粒酶活性。结果:两组的端粒酶阳性率分别为:A组0%、B组52.27%,B组端粒酶阳性率随涂布DMBA周数(病理分级)具有显著性差异(p<0.01或p<0.05)。实验性口腔白斑癌变过程中,端粒酶活性逐渐上升。结论:端粒酶可以作为口腔白斑癌变化学预防的替代性终点标记物监测口腔白斑癌变。
OBJECTIVE: To study the dynamic changes of telomerase activity during the carcinogenesis of cheek pouch leukoplakia, and to provide baseline information for exploring the possible mechanism of drug intervention in the carcinogenesis of oral leukoplakia. Methods: Saline method was used to establish the model of hamster cheek pouch carcinogenesis. 55 golden hamsters were divided into two groups: control group (group A) 5 and model group (group B) 50. Double-blind method to determine the pathological grade; TRAP-ELISA assay specimens telomerase activity. Results: The positive rates of telomerase in the two groups were 0% in group A and 52.27% in group B, respectively. The positive rate of telomerase in group B was significantly different from that in group DMBA (pathological grade) (p <0.01 or p <0.05). In the process of experimental oral leukosis, telomerase activity gradually increased. Conclusion: Telomerase can be used as a surrogate marker for the prevention of oral leukoplakia in the prevention of oral leukoplakia.