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慢活肝患者用熊脱氧胆酸(UDCA)后血清转氨酶水平下降的报道最近已被证实。有研究认为亲水性熊脱氧胆酸改善慢性肝病患者肝功能的部分原因是由于肠肝循环中胆汁酸池的亲水性与疏水性之间的平衡发生变化所致。然而,胆汁酸成份改变与其对肝功能影响之间的关系尚未被完全阐明。本实验旨在探讨慢活肝时两者之间的关系。方法:18例符合下列标准的患者参与本实验:(l)两年内肝活检确诊为慢活肝;(2)半年内至少有两次血清ALT值达正常值上限的2倍;(3)血清总胆红素小于2mg/dl;(4)临床、内镜及超声检查无门脉高压征象;(5)无嗜酒史及肝肿瘤。分别给予UDCA250、500、750mg/d,每种剂量治疗周期为二个月,连续三个周
The report of a decrease in serum aminotransferase levels in patients with slow-acting liver using ursodeoxycholic acid (UDCA) has recently been confirmed. Some studies suggest that hydrophilic ursodeoxycholic acid to improve liver function in patients with chronic liver disease in part due to changes in the balance between hydrophilicity and hydrophobicity of bile acid pool in the enterohepatic circulation changes. However, the relationship between changes in bile acid composition and its effect on liver function has not yet been fully elucidated. This experiment aims to explore the relationship between the slow-living liver. METHODS: Eighteen patients who met the following criteria were enrolled in this study: (1) Liver biopsy was diagnosed as slow-moving liver within two years; (2) Serum ALT was at least twice as high as twice the upper limit of normal within six months; (3) Serum Total bilirubin less than 2mg / dl; (4) clinical, endoscopic and ultrasonographic signs of portal hypertension; (5) no history of alcoholism and liver cancer. Were given UDCA250, 500,750mg / d, each dose of treatment for two months, three consecutive weeks