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目的:探讨格列美脲联合胰岛素治疗2型糖尿病的临床疗效。方法:对122例2型糖尿病患者采取不同的方案进行治疗,观察组应用格列美脲联合胰岛素,对照组仅应用胰岛素进行治疗,两组患者均给予糖尿病健康教育,制定科学、合理的营养饮食,指导、督促长期坚持体育锻炼等。对比两组患者治疗前后空腹血糖(FBG)、餐后2h血糖(2hBG)、体重指数(BMI)及糖化血红蛋白(HbA1c)等指标,评价格列美脲的应用价值。结果:观察组达标率以及FBG、2hBG、HbA1c几项指标的变化情况与对照组相比均具有明显的优势,整体疗效较好,且无严重不良反应发生。结论:格列美脲联合胰岛素治疗2型糖尿病,能够获得较单一应用胰岛素更为满意的临床疗效,是值得推广的治疗方案。
Objective: To investigate the clinical efficacy of glimepiride combined with insulin in the treatment of type 2 diabetes mellitus. Methods: 122 cases of type 2 diabetes were treated with different programs, the observation group with glimepiride combined with insulin, the control group was treated with insulin only, both groups were given diabetes health education, to develop a scientific and reasonable nutrition diet , Guidance, supervision and long-term adhere to physical exercise. The levels of fasting blood glucose (FBG), 2h postprandial blood glucose (2hBG), body mass index (BMI) and HbA1c were compared before and after treatment to evaluate the value of glimepiride. Results: The change rate of the observation group and the indexes of FBG, 2hBG and HbA1c all showed obvious advantages compared with the control group. The overall effect was good and no serious adverse reactions occurred. Conclusion: Glimepiride combined with insulin in the treatment of type 2 diabetes mellitus is more satisfactory than the single application of insulin, which is worth to be promoted.