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近年来,血小板功能和前列腺素代谢异常在冠状动脉粥样硬化发生和发展中的作用已日益受到重视,尤其是血栓素(TXA_2)-前列环素(PGI_2)平衡失调,可能是冠心病进展甚至心源性猝死的重要因素之一。本文报道口服硝苯啶对老年冠心病患者TXA_2和PGI_2的代谢产物-TXB_2和6-K-PGF_1α血浆浓度及其比值的影响,旨在探讨小剂量硝苯啶在冠心病防治中的作用。资料和方法一、一般资料:按1980年全国心血管病会议制定的标准,选择冠心病患者22例,其中男18、女4例,年龄55～75(平均66.5)岁。全部病例均有不同程度的胸闷和胸痛、心悸等心脏症状,其中15例有静息心电图上心肌缺血表现。糖尿病、肾病及甲亢等患者不列为本观察对象。
In recent years, the role of platelet function and prostaglandin metabolism in the development and progression of coronary atherosclerosis has been paid more and more attention, especially the imbalance of thromboxane (TXA 2) and prostacyclin (PGI 2), which may be the progression of coronary heart disease One of the important factors of sudden cardiac death. This article reports oral nifedipine in elderly patients with coronary heart disease TXA_2 and PGI_2 metabolites - TXB2 and 6-K-PGF1α plasma concentrations and their ratio, aimed to explore the small doses of nifedipine in the prevention and treatment of coronary heart disease. Materials and Methods I. General Information: According to the standards set by the National Conference on Cardiovascular Disease in 1980, 22 patients with coronary heart disease were selected, including 18 males and 4 females, aged 55-75 (average 66.5 years). All cases have varying degrees of chest tightness and chest pain, heart palpitations and other heart symptoms, of which 15 cases of resting myocardial ischemia performance. Diabetes, kidney disease and hyperthyroidism and other patients are not included in this observation.