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目的探讨辛伐他汀对急性脑梗死(AC I)患者血清肿瘤坏死因子α(TNF-α)及白细胞介素6(IL-6)水平变化的影响。方法将AC I患者64例随机分为辛伐他汀组32例和常规治疗组32例,分别于治疗前及治疗4周后行放射免疫分析法测定血清IL-6及TNF-α。另选同期健康体检的25例作为对照组。结果AC I组治疗前血清TNF-,αIL-6水平均明显高于对照组(均P<0.01)。辛伐他汀组治疗后血清TNF-α,IL-6水平均明显低于治疗前(均P<0.05),且低于常规治疗组(均P<0.05),差异有统计学意义;但仍高于对照组(均P<0.05)。常规治疗组患者治疗后血清TNF-,αIL-6降低不明显(P>0.05)。结论AC I患者应用辛伐他汀治疗使TNF-,αIL-6显著降低,有明显抗炎作用。
Objective To investigate the effect of simvastatin on serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in patients with acute cerebral infarction (ACI). Methods Sixty-four patients with ACI were randomly divided into simvastatin group (32 cases) and conventional treatment group (32 cases). Serum IL-6 and TNF-α were measured by radioimmunoassay before and after treatment for 4 weeks. Another 25 cases of the same period of physical examination as a control group. Results The levels of serum TNF- and αIL-6 in ACI group before treatment were significantly higher than those in control group (all P <0.01). The levels of serum TNF-α and IL-6 in simvastatin group were significantly lower than those before treatment (all P <0.05), and were lower than those in routine treatment group (all P <0.05), but the difference was statistically significant In the control group (all P <0.05). After treatment, the serum TNF- and aIL-6 levels were not significantly reduced in the conventional treatment group (P> 0.05). Conclusions The treatment with simvastatin in ACI patients significantly reduced the levels of TNF- and αIL-6 and markedly inhibited the anti-inflammatory effects.