口感是口腔给药系统(oral drug delivery system,ODDS)制剂处方研究设计的重要内容。传统的感官评价结果严重受制于受试者的个体差异,重现性较差,难以客观量化。鉴于此,介绍了其他学科领域口感评价的一些新技术、新方法,重点对药物在口腔中的味觉、黏附性、黏膜刺激性、沙砾感等新型评价方法进行了评述,以期为中药ODDS的质量评价及开发利用提供方法学借鉴。 Taste is an important part of the formulation design of oral drug delivery system (ODDS) formulations. The traditional sensory evaluation results are severely limited by the individual differences of the subjects, with poor reproducibility and difficulty in objective quantification. In view of this, some new techniques and new methods for evaluating palatability in other subject areas are introduced, and new evaluation methods such as taste, adhesion, mucosal irritation and gravel feeling in the oral cavity are emphatically reviewed in order to evaluate the quality of ODDS Evaluation and development to provide methodology to learn from.