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现已查明,哺乳动物和人的肺泡表面覆盖着一层表面活性物质(以下简称PS),肺脏疾患时,PS的代谢发生紊乱。不同性质的粉尘储留在肺脏所引起PS的改变不一,石英等致纤维化能力强的粉尘可使PS的含量明显升高。研究尘肺时PS的变化,对于进一步认识粉尘和肺脏间的相互作用、尘肺的发病机理等有所帮助。本文就目前国内外学者对PS的认识和实验性尘肺时PS变化的资料加以归纳,并就其在尘肺发生、发展过程和发病机理上的地位作如下探讨。
It has been identified that mammalian and human alveolar surface covered with a layer of surface active substances (hereinafter referred to as PS), lung disease, PS metabolism disorders. Different types of dust stored in the lungs caused by changes in the different PS, quartz and other fibers caused by the strong ability of the dust can make the PS content was significantly increased. Studying the changes of PS in pneumoconiosis is helpful for further understanding of the interaction between dust and lung and the pathogenesis of pneumoconiosis. This paper summarizes the current knowledge of PS in domestic and foreign scholars and the experimental data of PS changes in experimental pneumoconiosis, and discusses its status in the pathogenesis, development and pathogenesis of pneumoconiosis.