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Objective To investigate the effects of 12-lipoxygenase(12-LO)and angiotensinⅡ(AngⅡ)on the CIP/KIP family of cyclin-dependent kinase inhibitors(CKIs)p21,p27 and p57 related to cell hypertrophy.Methods Mesangial cells were treated with high glucose for 24hours and 48 hours respectively.12(S)-hydroxyeicosa-
Objective To investigate the effects of 12-lipoxygenase (12-LO) and angiotensinⅡ (AngⅡ) on the CIP / KIP family of cyclin- dependent kinase inhibitors (CKIs) p21, p27 and p57 related to cell hypertrophy .Methods Mesangial cells were treated with high glucose for 24hours and 48 hours respectively.12 (S) -hydroxyeicosa-