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目的：探讨白细胞介素８（ＩＬ－８）在再生障碍性贫血（再障）发病机制中的作用及与临床状况间的关系。方法：采用夹心酶联免疫吸附法检测２４例再障患者及２０名正常人外周血上清中ＩＬ－８水平。结果：再障患者ＩＬ－８水平显著高于正常对照（Ｐ＜０．０５），且重型再障组较慢性再障组显著增高（Ｐ＜０．０５），合并感染的再障患者ＩＬ－８含量升高更为显著（Ｐ＜０．００５）。结论：作为细胞趋化因子及造血负性调控因子的ＩＬ－８，在再障的病理过程中可能起着一定的作用，并对判断病情的严重程度及感染的存在具有一定的价值。
Objective: To investigate the role of interleukin-8 (IL-8) in the pathogenesis of aplastic anemia (aplastic anemia) and its relationship with clinical status. Methods: The level of IL-8 in peripheral blood of 24 patients with aplastic anemia and 20 normal subjects was detected by sandwich enzyme-linked immunosorbent assay. Results: The levels of IL-8 in patients with aplastic anemia were significantly higher than those in normal controls (P <0.05), and those in patients with severe AA were significantly higher than those in patients with chronic aplasia (P <0.05) 8 content increased more significantly (P <0.005). CONCLUSION: IL-8, a cytokine and hematopoietic negative regulatory factor, may play a role in the pathological process of aplastic anemia and may be of value in judging the severity of the disease and the existence of infection.