我们采用去甲肾上腺素(NE)和血液透析(HD)成功抢救1例大剂量氯氮平中毒所致顽固性休克患者,与以往报道不同,使用多巴胺(DA)无效。报告如下。女性,37岁,汉族。因自服氯氮平400片(25 mg/片)后神志不清,四肢抽搐2h于2001年10月2日22时由外院转入我科。既往有抑郁症2年及高血压病3年病史,常服用氯氮平25 mg tid,尼群地平10 mg tid。查体:体温37℃,心率100次/min,血压75/40 mm Hg,呼吸28次/min。中度昏迷,双侧瞳孔3 mm大小,对光反射迟钝。口唇发绀,口腔大量分泌物。双肺呼吸音粗,闻及痰鸣音。心音强,心律齐,心率100次/min。腹 We used norepinephrine (NE) and hemodialysis (HD) to successfully rescue one patient with intractable shock caused by high-dose clozapine poisoning. Unlike previous reports, dopamine (DA) was not effective. The report is as follows. Female, 37 years old, Han nationality. Because of clozapine 400 tablets (25 mg / tablet) unconsciousness, limbs twitch 2h at 2:00 on October 2, 2001 from outside the hospital transferred to our department. Previous depression 2 years and 3 years history of hypertension, often taking clozapine 25 mg tid, nitrendipine 10 mg tid. Physical examination: body temperature 37 ℃, heart rate 100 beats / min, blood pressure 75/40 mm Hg, breathing 28 beats / min. Moderate coma, bilateral pupil size of 3 mm, slow light reflex. Cyanosis lips, a lot of oral secretions. Breath sounds coarse lungs, smell and phlegm sounds. Heart sounds strong, heart rate Qi, heart rate 100 beats / min. belly