粘液高分泌在支气管哮喘、COPD等气道高分泌疾病的病理生理过程中具有重要影响。它可加重肺功能损害程度,增加疾病的病残率和病死率。一些药物虽能够影响粘液高分泌反应,但临床应用有限。本文主要阐述近年来非甾体抗高分泌药物的进展,以及对这些药物的新认识。 Mucus hypersecretion plays an important role in the pathophysiological process of bronchial asthma, COPD and other airway hypersecretion diseases. It can aggravate the degree of lung dysfunction, increase the morbidity and mortality of the disease. Although some drugs can affect mucus hypersecretion, but clinical application is limited. This article describes in recent years non-steroidal anti-secretory drugs progress, as well as new understanding of these drugs.