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霍乱毒素(CT)是霍乱弧菌分泌的不耐热肠毒素,具有很强的免疫原活性和佐剂活性,是当今研究最多且最深入的黏膜免疫佐剂之一。目前有关CT黏膜佐剂作用的机制尚不完全清楚,近来研究发现CT发挥黏膜免疫佐剂作用与其诱导Th17细胞分化密切相关。现就Th17细胞在CT发挥黏膜佐剂效应的机制作一综述。
Cholera toxin (CT) is a heat-labile enterotoxin secreted by Vibrio cholerae and has strong immunogenicity and adjuvant activity. It is one of the most studied and most in-depth mucosal immune adjuvants. At present, the mechanism of CT mucosal adjuvant is not yet fully understood. Recently, it was found that CT plays a role in mucosal immune adjuvant and is closely related to its induction of Th17 cell differentiation. The mechanism of Th17 cells playing mucosal adjuvant effect on CT is reviewed.