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糖尿病(DM)是动脉硬化及其并发症的重要危险因素,但人们尚未充分认识到DM是心力衰竭(HF)重要且独立的危险因素。弗明汉心脏研究发现,DM患者HF发生率是非DM患者的2～5倍。DM可进一步恶化HF的预后,明显增加HF患者的死亡率及住院率。两者常同时存在且预后很差。本文重点综述DM患者易于发生HF的机制以及药物治疗在预防2型DM患者发生HF中的作用。
Diabetes mellitus (DM) is an important risk factor for atherosclerosis and its complications, but it is not yet fully recognized that DM is an important and independent risk factor for heart failure (HF). The Framingham Heart Study found that the incidence of HF in DM patients was 2 to 5 times greater than in non-DM patients. DM can further worsen the prognosis of HF, significantly increase the mortality and hospitalization rate of HF patients. Both often coexist and the prognosis is poor. This article highlights the mechanisms underlying HF in patients with DM and the role of drug therapy in the prevention of HF in patients with type 2 DM.