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目的 评价脱氧胶原吡啶交联 (DPD)及尿微量白蛋白 (MA)、微球蛋白 (α1 -M)、转铁蛋白 (TRF)在妊高征早期诊断中的意义。 方法 收集101例孕28～32周孕妇清晨空腹中段尿 ,采用化学发光免疫法测定尿DPD ;速率散射比浊法测定MA、α1-M、TRF。按最终是否发生妊高征分成两组。其中妊高征组20例 ,正常妊娠组81例。 结果 妊高征组尿DPD/Cr为11.28±2.42 ;正常组为9.17±2.11,两组差别有显著性意义 (t=3.58,P<0.01) ;尿MA妊高征组为 (0.63±0.30)mg/L,正常组为 (0.42±0.08)mg/L,两组差别有显著性意义 (t=3.15 ,P<0.01) ;尿α1-M妊高征组为 (0.39±0.17)mg/L ,正常组为 (0.87±0.24)mg/L ,两组差别有显著性意义 (t=4.62,P<0.01) ;尿TRF妊高征组为 (0.39±0.17)mg/L,正常组为 (0.33±0.01)mg/L,两组差别无显著性意义 (t=1.72,P>0.05)。 结论 尿DPD、MA、α1-M排泄在妊高征出现之前已经增加 ,测定尿DPD、MA、α1-M可为妊高征的早期诊断提供依据
Objective To evaluate the significance of deoxygenated collagen (DPD), urinary microalbumin (MA), microglobulin (α1-M) and transferrin (TRF) in early diagnosis of PIH. Methods Urine was collected from 101 pregnant women with gestational age of 28 to 32 weeks in the early morning fasting urine. The urine DPD was measured by chemiluminescence immunoassay. The contents of MA, α1-M and TRF were measured by speed nephelometry. According to whether the final pregnancy-induced hypertension divided into two groups. Among them, there were 20 cases of PIH group and 81 cases of normal pregnancy group. Results The urinary DPD / Cr in PIH group was 11.28 ± 2.42 and that in normal group was 9.17 ± 2.11, with significant difference between the two groups (t = 3.58, P <0.01) (0.42 ± 0.08) mg / L in the normal group (t = 3.15, P <0.01), and (0.39 ± 0.17) mg / L in the urine α1-M pregnancy induced hypertension group (0.87 ± 0.24) mg / L in normal group, the difference between the two groups was significant (t = 4.62, P <0.01) 0.33 ± 0.01) mg / L, no significant difference between the two groups (t = 1.72, P> 0.05). Conclusions Excretion of urinary DPD, MA and α1-M have been increased before the occurrence of PIH. The determination of urinary DPD, MA and α1-M may provide evidence for the early diagnosis of PIH