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目的:优选穴敷喘平凝胶贴剂的最佳提取工艺。方法:采用正交试验设计法,以浸膏得率和盐酸麻黄碱含量为评价指标,考察乙醇体积分数,乙醇用量,提取时间3个因素对浸膏得率及有效成分的影响,优选最佳提取工艺。结果:影响提取效果的因素顺序为:乙醇体积分数>乙醇用量>提取时间,乙醇体积分数对提取有显著性影响。结论:优选得到的穴敷喘平凝胶贴剂的最佳提取工艺为,加70%乙醇8倍量,提取2次,每次1 h。
Objective: To optimize the best extraction process of acupoint cream. Methods: The orthogonal experiment design was used to evaluate the extraction yield and content of ephedrine hydrochloride. The effects of ethanol volume fraction, ethanol dosage and extraction time on extraction yield and active ingredients were studied. Extraction process. Results: The order of factors affecting the extraction efficiency was ethanol volume fraction> ethanol amount> extraction time, ethanol volume fraction had a significant effect on the extraction. Conclusion: The optimum extraction process of acupoint-ointment gel patch is as follows: add 8 times of 70% ethanol and extract twice for 1 hour.