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报告1例化疗相关的表型转换型成人急性杂合自血病。病例介绍患者男,19岁,因渐进性头昏、发热和出血3周于1990年11月6日人院。既往健康,无毒药物接触史。家族中父母和唯一胞姐均健康。查体:面色苍白,巩膜无黄染,前下胸和双下肢瘀点散见。全身浅表淋巴结广泛肿大如黄豆。胸骨压痛。心肺(-)。肝肋下刚及,脾肋下2cm。Hb96g/L,Pt21×10~9/L,WBC70×10~9/L,分类见原、早幼粒各14%,淋巴4%。骨髓增生极度活跃,粒红比190:1。原粒22.5%,早幼粒33%,红、淋巴系严重抑制。全片巨核细胞36只,血小板型
One case of chemotherapy-associated phenotype-switching adult acute heterozygous leukemia was reported. Case description Male patient, 19 years old, due to progressive dizziness, fever and bleeding 3 weeks in November 6, 1990 hospital. Past health, non-toxic drug exposure history. Parents and only sister in the family are healthy. Physical examination: pale, Sclera no yellow dye, the lower chest and lower extremity stasis scattered see. Systemic superficial lymph nodes swelling, such as soybeans. Sternal tenderness. Cardiopulmonary (-). Just under the ribs of the liver, spleen ribs 2cm. Hb96g / L, Pt21 × 10 ~ 9 / L, WBC70 × 10 ~ 9 / L, see the original classification, promyelocytic 14%, lymph 4%. Myeloid hyperplasia is extremely active, with a grainy ratio of 190: 1. 22.5% of the original particles, promyelocytic 33%, red, lymphatic system was severely inhibited. Whole-cell megakaryocyte 36, platelet type