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目的：探讨抗抑郁剂联合认知疗法治疗门诊抑郁症的临床效果。方法将76例门诊抑郁症患者随机分为两组，均给予常规抗抑郁剂治疗，研究组联合认知疗法，观察10周，随访12个月。采用汉密顿抑郁量表、临床疗效总评量表评定临床疗效，生活质量综合评定问卷评定生活质量，统计患者服药依从性和复发率。结果治疗后两组汉密顿抑郁量表、临床疗效总评量表评分均较治疗前显著下降（P＜0．01），生活质量综合评定问卷总分及躯体健康、心理健康、社会功能维度评分均较治疗前显著升高（ P＜0．05或0．01）。治疗10周末两组总有效率比较差异无显著性（χ2＝0．00，P＞0．05）。随访第12个月研究组服药依从性显著高于对照组，复发率显著低于对照组（χ2＝8．89、10．83，P＜0．01）。结论抗抑郁剂联合认知疗法能快速缓解门诊抑郁症患者的抑郁症状，提高服药依从性及生活质量，降低复发率。“,”Objective To explore the efficacy of antidepressants combined with cognitive therapy in outpa-tients with depression .Methods Seventy-six outpatients with depression were randomly into two groups , both groups were treated with routine antidepressants ,and research group was plus cognitive therapy for 10 weeks and were traced for 12 months .Efficacies were assessed with the Hamilton Depression Scale (HAMD) and Clinical Global Impression (CGI) and qualities of life with the Generic Quality of Life Inven-tory-74(GQOLI-74) ,patients’ compliance and relapse rate added up .Results After treatment the HAMD and CGI scores of both groups lowered more significantly compared with pretreatment (P<0 .01) ,the to-tal ,somatic and mental health and social function scores of the GQOLI-74 heightened more significantly (P0 .05) .At the end of the 12th month follow-up ,drug compliance rate was significantly high-er and relapse rate lower in research than control group (χ2 =8 .89 ,10 .83 ,P<0 .01) .Conclusion Anti-depressants combined with cognitive therapy could quickly relieve depressive symptoms of outpatients with depression ,improve drug compliance and quality of life ,and reduce relapse rate .