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目的观察复方丹参注射液治疗百草枯中毒患者的效果。方法临床观察设常规治疗组(对照组)和复方丹参注射液加常规治疗组(观察组)。临床观察X线胸片、血气、肝肾功能和病死率。结果临床出现严重肺损害(肺门结构紊乱、肺纤维化等)的病例观察组占41.9%,对照组67.6%。两组差异有统计学意义(P<0.05)。观察组治疗前后PaO2增高,SGPT、总胆红素和Cr降低;而对照组仅Cr明显降低。观察组病死率占48.3%;对照组病死率占61.7%,两组比较差异有统计学意义(P<0.05)。结论复方丹参与综合治疗对改善百草枯中毒致肺损害、降低病死率有一定疗效。
Objective To observe the effect of compound Salvia miltiorrhiza injection on patients with paraquat poisoning. Methods Clinical observation was divided into routine treatment group (control group) and compound Danshen injection plus conventional treatment group (observation group). Clinical observation of X-ray, blood gas, liver and kidney function and mortality. Results Clinical observation showed 41.9% cases of severe lung injury (hilar structural disorder, pulmonary fibrosis, etc.) in the observation group and 67.6% in the control group. The difference between the two groups was statistically significant (P <0.05). The observation group before and after PaO2 increased, SGPT, total bilirubin and Cr decreased; while the control group only Cr decreased significantly. Case fatality rate was 48.3% in the observation group and 61.7% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion Salvia miltiorrhiza combined with comprehensive treatment to improve paraquat poisoning caused by lung damage and reduce mortality have a certain effect.