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用放射免疫方法检测不同期别的煤工尘肺（ＣＷＰ）患者血浆中前列腺素Ｅ２（ＰＧＥ２）的水平，同时用体外细胞培养方法将煤尘作用于肺泡巨噬细胞（ＡＭ）后对其分泌ＰＧＥ２的情况进行比较。结果表明：ＣＷＰ患者血浆中ＰＧＥ２的水平明显高于对照组；不同期别的病人血浆中ＰＧＥ２含量不一样．表现为Ⅰ＞Ⅱ＞Ⅲ，经统计分析．Ｐ＜０．０１．体外实验显示随着煤尘对ＡＭ作用浓度增加．培养时间延长，ＡＭ培养上清液中ＰＧＥ２含量升高。体内、体外的研究结果均证实煤尘作用于ＡＭ后，可以改变ＡＭ的分泌功能，使其分泌大量的ＰＧＥ２．提示：ＣＷＰ的发生发展与血浆中ＰＧＥ２的水平有一定的关系。
Radioimmunoassay was used to detect plasma prostaglandin E2 (PGE2) levels in different stages of coal worker’s pneumoconiosis (CWP) patients. Meanwhile, PGE2 was secreted by coal dust in alveolar macrophages (AM) after in vitro cell culture The situation is compared. The results showed that the level of PGE2 in plasma of CWP patients was significantly higher than that in the control group. The plasma levels of PGE2 in different periods were different. The performance of Ⅰ> Ⅱ> Ⅲ, the statistical analysis. P <0.01. In vitro experiments show that the effect of coal dust on AM increases. Prolonged incubation time, AM culture supernatant PGE2 content increased. In vivo and in vitro studies have confirmed the role of coal dust in the AM, AM secretion can change the function of secretion of large amounts of PGE2. Tip: The occurrence and development of CWP and plasma levels of PGE2 have a certain relationship.