应用动物模型研究人类的秃发已有很长的历史,在男性秃发的研究中,人们建立了短尾猴模型,AGA小鼠模型及用于大批药物筛选的毛发周期转换测定法。实验动物的先天性无毛也一直受到关注,不但有数量众多的大、小鼠先天性无毛突变的报道,而且有胸腺缺失的裸鼠这一特殊模型。近几年关于生长期脱发和斑秃的动物实验研究也发展迅速,而建它于生物支持系统上的离体皮肤模型,又为秃发研究提供了新的途径。 Animal models of human alopecia have been used for a long time. In the study of male alopecia, cynomolgus monkey model, AGA mouse model and hair cycle transformation assay were used for large-scale drug screening. Congenital gingival in experimental animals has also drawn attention. Not only is there a large number of large and mouse congenital hairless mutations reported, but also a special model of nude mice lacking thymus. In recent years, animal experiments on alopecia arena and alopecia areata have also developed rapidly. However, the ex vivo skin model built on the biologic support system provides a new way for alopecia.