Prohibitin(PHB)是近年来发现的一种具有多种生物学功能的蛋白分子,可参与细胞周期调控、蛋白质折叠、转录调节等[1-2],PHB与肿瘤发生发展的关系存在两种截然不同的观点,PHB最初被认为是肿瘤发生和细胞增殖的负调节因子,但大量研究发现,PHB在多种肿瘤组织中高表达[3],有研究证明PHB还具有抗凋亡作用[4],其确切的分子功能尚有待于进一步深入研究。 Prohibitin (PHB) is a protein molecule with many biological functions found in recent years. It can participate in cell cycle regulation, protein folding, transcription regulation, etc. [1-2]. There are two kinds of relationship between PHB and tumorigenesis In different perspectives, PHB was initially considered as a negative regulator of tumorigenesis and cell proliferation. However, a large number of studies have found that PHB is overexpressed in a variety of tumor tissues [3]. Studies have shown that PHB also has an anti-apoptotic effect [4] Its exact molecular function remains to be further studied.