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目的:探讨乳腺癌组织中VEGF、VEGF-C、flt-4蛋白的表达水平、相互关系及临床意义。方法:采用免疫组织化学ABC法,检测82例乳腺癌石蜡标本中VEGF、VEGF-C、flt-4蛋白的表达水平。结果:乳腺癌标本中VEGF、VEGF-C、flt-4蛋白的阳性表达率分别为57.3%、46.3%、50.0%,VEGF-C与flt-4蛋白的表达呈正相关。但与乳腺癌组织病理学分型、肿瘤大小和分级无关。结论:VEGF-C、flt-4蛋白的表达与乳腺癌淋巴结转移有关,并可能协同作用于淋巴结转移过程。
Objective: To investigate the expression, correlation and clinical significance of VEGF, VEGF-C and flt-4 in breast cancer. Methods: Immunohistochemical ABC method was used to detect the expression of VEGF, VEGF-C and flt-4 protein in 82 cases of breast cancer. Results: The positive rates of VEGF, VEGF-C and flt-4 in breast cancer specimens were 57.3%, 46.3% and 50.0%, respectively. There was a positive correlation between VEGF-C and flt-4 protein expression. However, histopathological classification of breast cancer, tumor size and grade has nothing to do. CONCLUSION: The expression of VEGF-C and flt-4 protein is correlated with lymph node metastasis in breast cancer and may play a synergistic role in lymph node metastasis.