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该文应用免疫组化法研究大肠癌和大胸腺癌组织中P16、Rb基因蛋白的表达及意义。32例大肠癌P16、Rb阳性病例率分别为34．3％和40．6％，40例腺瘤则分别为72．5％和37．5％。P16阳性病例率在大肠癌各病理组织类型中无明显差异，但Rb阳性病例率高分化腺癌较明显低于其他类型大肠癌（P＞0.05）；ATP（0～＋）级腺瘤P16阳性病例率明显高于ATP（＋＋～＋＋＋）级腺癌（P＜0.01）;ATP（O～＋）级腺瘤Rb阳性病例率较明显低于ATP（＋＋～＋＋＋）级脉瘤（P＞0.05）.揭示P16、Rb蛋白可能与大肠癌发生发展、生物学行为等有较密切关系。
The expression and significance of P16 and Rb gene proteins in colorectal cancer and large thymic carcinoma were studied by immunohistochemistry. The positive rates of P16 and Rb in 32 cases of colorectal cancer were 34.3% and 40.6%, respectively, and those in 40 cases were 72.5% and 37.5%, respectively. There was no significant difference in the rate of P16 positive cases among the pathological types of colorectal cancer, but the rate of Rb positive cases was significantly lower than that of other types of colorectal cancer (P>0.05); ATP (0~+) grade adenomas were positive for P16 The rate of cases was significantly higher than that of ATP(++～+++) grade adenocarcinoma(P<0.01). The rate of Rb positive cases of ATP(O～+) grade adenomas was significantly lower than that of ATP(++～+++) grade tumors(P>0.05). ). Reveal that P16, Rb protein may have a close relationship with the occurrence and development of colorectal cancer, biological behavior.