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目的 :探讨增殖细胞核抗原 (proliferating cell nuclear antigen,PCNA)在中耳胆脂瘤上皮中的表达和定位以及与中耳炎症的关系。方法 :采用 PCNA单克隆抗体对 16例中耳胆脂瘤组织和 6例正常外耳道皮肤 ,面部皮肤以及鼓膜进行免疫定位检测。结果 :PCNA阳性细胞仅见于正常外耳道、面部皮肤和鼓膜的基底细胞层和棘细胞层的开始部位 ,亦可见于胆脂瘤组织上皮全层。上皮下炎性细胞浸润愈重 ,PCNA阳性细胞率愈高。结论 :中耳胆脂瘤上皮组织具有过度增殖能力。上皮下炎症反应可能是角化细胞过度增殖的一个原因
Objective: To investigate the expression and localization of proliferating cell nuclear antigen (PCNA) in the middle ear cholesteatoma epithelium and its relationship with middle ear inflammation. Methods: 16 cases of middle ear cholesteatoma tissue and 6 cases of normal external auditory canal skin, facial skin and tympanic membrane were immunolocalized by PCNA monoclonal antibody. Results: PCNA positive cells only found in the normal external auditory canal, facial skin and tympanic membrane basal cell layer and the beginning of the spinous cell layer can also be found in the cholesteatoma epithelial layer. The heavier the infiltration of inflammatory cells in the epithelium, the higher the rate of PCNA-positive cells. Conclusion: Middle ear cholesteatoma epithelial tissue has the ability of hyperproliferation. Subepithelial inflammatory response may be a cause of keratinocyte hyperproliferation