A new framework for networked control system based on Generalized Predictive Control (GPC) is proposed in this paper. Clock-driven sensors, event-driven controller, and clock-driven actuators are required in this framework. A queuing strategy is proposed to overcome the network induced delay. Without redesigning, the proposed framework enables the existing GPC controller to be used in a network environment. It also does not require clock synchronization and is only slightly affected by bad network condition such as package loss. Various experiments are designed over the real network to test the proposed approach,which verify that the proposed approach can stabilize the Networked Control System (NCS) and is robust.