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本文旨在探讨克霉唑栓与乳酸杆菌活菌胶囊联合治疗复杂性外阴阴道假丝酵母病(VVC)的临床疗效。将84例就诊于江苏省中西医结合医院妇产科的复杂性VVC患者随机平均分为两组:治疗组给予阴道内放置克霉唑栓与乳酸杆菌活菌胶囊联合治疗;对照组单用阴道内放置克霉唑栓。结果显示,治疗组复杂性VVC 42例(失访2例),29例治愈,8例显效,总有效率为88.10%;对照组复杂性VVC42例(失访3例),20例治愈,9例显效,总有效率为69.05%。两组总有效率差异有统计学意义(P<0.05)。两组治愈及显效者均在治疗停药后12周复查。治疗组失访2例,复发3例,复发率为7.65%;对照组失访3例,复发9例,复发率为23.08%。结果提示,克霉唑栓与乳酸杆菌活菌胶囊联合治疗复杂性VVC安全、有效,可在临床推广。
This article aims to investigate the clinical efficacy of clotrimazole suppository and Lactobacillus live capsule in the treatment of complex vulvovaginal candidiasis (VVC). Eighty-four patients with complicated VVC who were referred to the Department of Obstetrics and Gynecology, Hospital of Integrative Medicine of Jiangsu Province were randomly divided into two groups: the treatment group was treated with intra-vaginal clotrimazole suppository and Lactobacillus live-cell combination therapy; the control group was treated with vaginal Place clotrimazole inside. The results showed that in the treatment group, 42 cases were complicated with VVC (2 cases were lost to follow-up), 29 cases were cured and 8 cases were markedly effective. The total effective rate was 88.10% Cases markedly effective, the total effective rate was 69.05%. The total effective rate between the two groups was statistically significant (P <0.05). Two groups were cured and markedly effective after treatment discontinuation of 12 weeks review. The treatment group lost 2 cases, 3 cases of recurrence, the recurrence rate was 7.65%; control group lost 3 cases, 9 cases of recurrence, the recurrence rate was 23.08%. The results suggest that the combination of clotrimazole suppository and Lactobacillus live capsule in the treatment of complex VVC is safe and effective and can be clinically promoted.