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目的:探讨血清脂联素(APN)及视黄醇结合蛋白4(RBP4)水平在2型糖尿病(T2DM)大血管病变中的变化及意义。方法:选取T2DM并发大血管病变者36例(Ⅰ组)、单纯T2DM者38例(Ⅱ组)和健康体检者32例(Ⅲ组),采用ELISA法检测其血清标本的APN和RBP4浓度,同时检测血糖血脂及糖化血红蛋白(HbA1c)浓度。结果:Ⅰ组血清APN的浓度为(3.5±0.8)mg/L,显著低于Ⅱ组(7.8±0.9)mg/L和Ⅲ组(11.6±1.6)mg/L;Ⅰ组血清RBP4浓度为(23.1±2.8)mg/L,显著高于Ⅱ组(13.6±1.5)mg/L和Ⅲ组(10.2±1.7)mg/L。APN浓度与空腹血糖、甘油三酯、低密度脂蛋白胆固醇和HbA1c水平呈负相关(r=-0.402、-0.322、-0.316、-0.518和-0.469,均P<0.05);而RBP4与上述指标呈正相关(r=0.486、0.347、0.396、0.401和0.355,均P<0.05),与高密度脂蛋白胆固醇呈负相关(r=-0.426,P<0.05)。结论:血清ANP和RBP4检测对T2DM大血管病变具有重要的预测价值。
Objective: To investigate the changes and significance of serum adiponectin (APN) and retinol binding protein 4 (RBP4) levels in type 2 diabetes mellitus (T2DM) macrovascular disease. Methods: Totally 36 patients with T2DM complicated with macrovascular disease (group Ⅰ), 38 patients with simple T2DM (group Ⅱ) and 32 healthy subjects (group Ⅲ) were selected. Serum APN and RBP4 concentrations were detected by ELISA Blood glucose and glycosylated hemoglobin (HbA1c) concentrations were measured. Results: Serum APN concentration in group Ⅰ was (3.5 ± 0.8) mg / L, which was significantly lower than that in group Ⅱ (7.8 ± 0.9) mg / L and group Ⅲ (11.6 ± 1.6) mg / 23.1 ± 2.8) mg / L, which was significantly higher than those in group Ⅱ (13.6 ± 1.5) mg / L and group Ⅲ (10.2 ± 1.7) mg / L. APN concentration was negatively correlated with fasting blood glucose, triglyceride, low density lipoprotein cholesterol and HbA1c (r = -0.402, -0.322, -0.316, -0.518 and -0.469, all P <0.05) (R = 0.486,0.347,0.396,0.401 and 0.355, both P <0.05), but negatively correlated with high density lipoprotein cholesterol (r = -0.426, P <0.05). Conclusion: Serum ANP and RBP4 detection of T2DM macrovascular disease has important predictive value.