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目的探讨扶正化瘀平喘法对哮喘发作患儿血浆内皮素(ET)、肿瘤坏死因子α(TNFα)及免疫功能的影响。方法将95例哮喘发作患儿随机分为治疗组和对照组,治疗组49例采用扶正化瘀平喘法配合舒利迭治疗,对照组46例应用舒利迭治疗。观察两组病例临床疗效及治疗前后患儿细胞因子血浆ET、TNFα、白细胞介素5(IL5)、白细胞介素8(IL8)的含量,免疫功能及肺功能(FEV1、FEV%)变化。结果治疗组在临床疗效,血浆ET、TNFα、IL5、IL8的降低,免疫功能及肺功能(FEV1、FEV%)的改善方面明显优于对照组(P<0.05)。结论扶正化瘀平喘法能有效降低哮喘发作患儿细胞因子含量,缓解气道炎性反应。
Objective To investigate the effects of Fuzheng Huayu Pingchuan Decoction on plasma endothelin (ET), tumor necrosis factor α (TNFα) and immune function in asthmatic children. Methods Ninety-five children with asthma were randomly divided into treatment group and control group. Forty-nine patients in the treatment group were treated with Fuzheng Huayu Pingchuan Decoction combined with seretide, and 46 in the control group were treated with seretide. To observe the clinical curative effect of two groups of patients before and after treatment, the contents of ET, TNFα, IL-5, IL-8, immune function and pulmonary function (FEV1, FEV% Results The treatment group was significantly better than the control group (P <0.05) in terms of clinical efficacy, reduction of plasma ET, TNFα, IL5 and IL8, improvement of immune function and pulmonary function (FEV1, FEV%). Conclusion Fuzheng Huayu Pingchuan Fa can effectively reduce the content of cytokines in asthmatic children and relieve airway inflammatory reaction.