1988年10月,在英国曼彻斯特市 Paterson 肿瘤研究所举行了第23届 Paterson 专题讨论会。该年度的讨论主题是“人类乳腺癌的遗传学”。其主旨概括三个方面:第一,回顾乳腺癌遗传倾向性的证据;第二,检查乳腺肿瘤起始(initiation)与演进(progtession)过程中所发生的遗传学改变;第三,考虑可能的检测方法以及对高危妇女的咨询等问题。本文为这次会议的论文。 In October 1988, the 23rd Paterson Symposium was held at the Paterson Cancer Institute in Manchester, England. The theme of the year’s discussion was “The genetics of human breast cancer.” Its purpose is summarized in three aspects: first, to review evidence of genetic predisposition to breast cancer; second, to examine the genetic changes that occur during the initiation and evolution of breast tumors; and third, to consider possible Test methods and counseling for high-risk women. This article is the paper for this meeting.