非酒精性脂肪性肝病(NAFLD)是指除外酒精和其他明确损肝因素所致的、以肝细胞脂肪变性和脂质沉积为主要特征的临床病理综合征。非酒精性脂肪性肝炎(NASH)是NAFLD病程进展中的主要阶段。近年多项研究发现肠源性内毒素血症与NASH关系密切,本文就肠源性内毒素血症所致的肥胖和肝脏损伤对NASH发生的影响作一综述。 Non-alcoholic fatty liver disease (NAFLD) refers to the exception of alcohol and other factors that specifically damage the liver caused by hepatocellular steatosis and lipid deposition as the main feature of clinical pathological syndrome. Non-alcoholic steatohepatitis (NASH) is the major stage in the progression of NAFLD. In recent years, many studies have found that gut-derived endotoxemia is closely related to NASH. This article reviews the effects of obesity and liver damage caused by enterogenous endotoxemia on NASH.