论文部分内容阅读
葫芦素甙的抗白血病活性已引起了人们的注意.我们用硅胶柱层离方法从葫芦科雪胆属植物(Hymsleya Sp.贵州产)的块根中分离到一种新的葫芦素甙,命名为雪胆甲素甙,分子式C_(38)H_(60)O_(13),熔点154.2～158.2℃,[a]_D~7+44°(C=1,乙醇),味极苦,易溶于乙醇、氯仿,难溶于乙醚、水.红外光谱v_(max)~(KBr)cm~(-1):3480(-OH),1700,1685(C=0).~1H核磁共振谱(250MHz,HMDS为内标,C_5D_5N为溶剂)δ:4.56(双峰,1H,J_(1’2’)=7.5周/秒,I’-H).根据J_(1’2’)=7.5周/秒,判定为β型甙·~(13)C核磁共振谱(~(13)C50.3MHz,TMS为内标,C_5D_5N为溶剂)见表.
The anti-leukemia activity of cucurbitacin has attracted attention. We isolated a new cucurbitacin from the roots of the genus Camptotheca (Hymsleya Sp. in Guizhou) by silica gel column delamination. Xuedansu tablet, molecular formula C_(38)H_(60)O_(13), melting point 154.2~158.2°C, [a]_D~7+44°(C=1, ethanol), bitter taste, soluble Ethanol, chloroform, insoluble in ether, water. Infrared spectra v_(max)~(KBr)cm~(-1):3480(-OH),1700,1685(C=0).~1H NMR spectra (250MHz HMDS is the internal standard and C_5D_5N is the solvent) δ: 4.56 (doublet, 1H, J_(1’2’) = 7.5 cycles/second, I’-H). According to J_(1’2’) = 7.5 weeks/ Second, it is judged as β-type 甙 · ~ (13) C NMR spectrum (~(13)C50.3MHz, TMS is internal standard, C_5D_5N is solvent).